University College Dublin

Systems Biology Ireland investigates new therapeutic approaches to disease on a systemic level using a combination of traditional wet-lab experimental analyses with computational modelling and simulation. The Eissner Group’s focus is on endothelial and mesenchymal stem cells in transplant medicine and oncology, i.e. the monitoring and preventing endothelial-specific adverse immunological reactions in transplant settings.

Role within COVend

WP5: Endothelial Cell Assessment

In WP5 we investigate the influence of COVID-19-triggered cytokines, as known to be present in patients’ sera, on viability, immunological as well as phenotypic changes, and transendothelial migration across human microvascular pulmonary endothelial cells. We also assess the protective role of FX06 to interfere with these pro-inflammatory actions and the underlying mechanism of action of the drug with wet and dry lab approaches.


Prof Günther Eißner, PhD

PI and wet lab supervisor of WP5

Prof Vadim Zhernovkov, PhD

Co-PI and dry lab supervisor of WP5

Zhiran Wang, M.Sc.

PhD Student, wet lab researcher of WP5

Dmitrii Lebedev, M.Sc.

Research Assistant, dry lab researcher of WP5

Sudharshan Rao, M.Sc.

Research Scientist, wet lab researcher of WP5