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Systems Biology Ireland investigates new therapeutic approaches to disease on a systemic level using a combination of traditional wet-lab experimental analyses with computational modelling and simulation. The Eissner Group’s focus is on endothelial and mesenchymal stem cells in transplant medicine and oncology, i.e. the monitoring and preventing endothelial-specific adverse immunological reactions in transplant settings.
WP5: Endothelial Cell Assessment
In WP5 we investigate the influence of COVID-19-triggered cytokines, as known to be present in patients’ sera, on viability, immunological as well as phenotypic changes, and transendothelial migration across human microvascular pulmonary endothelial cells. We also assess the protective role of FX06 to interfere with these pro-inflammatory actions and the underlying mechanism of action of the drug with wet and dry lab approaches.
PI and wet lab supervisor of WP5
Co-PI and dry lab supervisor of WP5
PhD Student, wet lab researcher of WP5
Research Assistant, dry lab researcher of WP5
Research Scientist, wet lab researcher of WP5
Funded by the European Union. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the European Health and Digital Executive Agency (HADEA). Neither the European Union nor the granting authority can be held responsible for them.
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