Unlocking endothelial barrier restoration: FX06 in systemic capillary leak syndrome and beyond

Authors: Maddalena Alessandra Wu, Laura Locatelli, Chiara Cogliati, Riccardo Colombo, Jeanette A. Maier

Publication: Biomedicine & Pharmacotherapy, published online: 18 January 2024

Microvascular Leakage as Therapeutic Target for Ischemia and Reperfusion Injury

Authors: Kloka, J.A.; Friedrichson, B.; Wülfroth, P.; Henning, R.; Zacharowski, K.

Publication: Cells, published online: 9 May 2023

Artificial intelligence research in the COVend COVID-19 clinical trial project

Authors: Alpo Olavi Värri, Antti Kallonen, Tunc Asuroglu, Mark van Gils

Publication: Finnish Journal of eHealth and eWelfare, published online: 20 April 2023

Potential of FX06 to prevent disease progression in hospitalized non‑intubated COVID‑19 patients — the randomized, EU‑wide, placebo‑controlled, phase II study design of IXION

Authors: Jan Kloka, Benjamin Friedrichson, Stephanie Dauth, Ann Christina Foldenauer, Anita Bulczak-Schadendorf, Maria J. G. T. Vehreschild, Francisco Maio Matos, Antoni Riera-Mestre, Antoinette D. I. van Asselt, Edoardo De Robertis, Vilma Traskaite Juskeviciene, Patrick Meybohm, Dana Tomescu, Karine Lacombe, Coen D. A. Stehouwer & Kai Zacharowski on behalf of the IXION Collaboration Group

Publication: Trials, published online: 19 August 2022

Do-not-intubate’ orders in patients assisted by noninvasive respiratory support for acute hypoxaemic failure caused by coronavirus disease 2019; a systematic review and meta-analysis

Authors: Cammarota, Gianmaria; Esposito, Teresa; Simonte, Rachele; Messina, Antonio; Cecconi, Maurizio; Vaschetto, Rosanna; Vetrugno, Luigi; Navalesi, Paolo; Azzolina, Danila; Robba, Chiara; Pelosi, Paolo; Longhini, Federico; Maggiore, Salvatore M.; De Robertis, Edoardo

Publication: European Journal of Anaesthesiology and Intensive Care, published online: 18 February 2023

Mini Review: Co-Existing Diseases and COVID-19 — A One Way Ticket?

Authors: Mantė Eidininkienė, Jelena Cesarskaja, Simona Talačkaitė, Vilma Traškaitė-Juškevičienė, Andrius Macas

Publication: PubMed, published online: 14 April 2022

Entering the new digital era of intensive care medicine: an overview of interdisciplinary approaches to use artificial intelligence for patients’ benefit

Authors: Oliver Old; Benjamin Friedrichson; Kai Zacharowski; Jan Andreas Kloka

Publication: European Journal of Anaesthesiology and Intensive Care, published online: 14 February 2023

FX06-COVID: Improvement of arterial oxygenation in intensive care patients with a severe course of COVID-19

Original title: FX06-COVID: Verbesserung der Oxygenierung durch FX06 in Intensivpatienten mit schweren Verläufen von COVID-19
Authors: Kai Zacharowski and Studiengruppe FX06-COVID

Publication: Der Anaesthesist, published online: 01 October 2020

Fibrin-derived peptide Bβ15-42 (FX06) as salvage treatment in critically ill patients with COVID-19-associated acute respiratory distress syndrome

Authors: Elisabeth H. Adam, Benedikt Schmid, Michael Sonntagbauer, Peter Kranke, Kai Zacharowski, and Patrick Meybohm

Publication: Crit Care, published: 24 September 2020

Publication: Der Anaesthesist, published online: 01 October 2020

Vascular Leak and Hypercytokinemia Associated with Severe Fever with Thrombocytopenia Syndrome Virus Infection in Mice

Authors: Jonna B. Westover, Brady T. Hickerson, Arnaud J. Van Wettere, Brett L. Hurst, Jacqueline P. Kurz, Ashley Dagley, Petra Wülfroth, Takashi Komeno, Yousuke Furuta, Thomas Steiner, and Brian B. Gowen

Publication: Pathogens, published: 21 September 2019

Combined peri-ischemic administration of Bß15–42 in treating ischemia reperfusion injury of the mouse kidney

Authors: Anja Urbschat, Katrin Rupprecht, Kai Zacharowski, Nicholas Obermüller, Bertram Scheller, Johannes Holfeld, Can Tepeköylü, Rainer Hofmann, and Patrick Paulus

Publication: Microvascular Research, published: 21 September 2019

The Fibrin-Derived Peptide Bß15-42 (FX06) Ameliorates Vascular Leakage and Improves Survival and Neurocognitive Recovery: Implications From Two Animal Models of Cardiopulmonary Resuscitation

Authors: Stefan Bergt, Matthias Gruenewald, Claudia Beltschany, Andrea Grub, Tobias Neumann, Martin Albrecht, Brigitte Vollmar, Kai Zacharowski, Jan P. Roesner, and Patrick Meybohm

Publication: Microvascular Research, published: October 2016

Severe Ebola virus disease with vascular leakage and multiorgan failure: treatment of a patient in intensive care

Authors: Timo Wolf, Gerrit Kann, Stephan Becker, Christoph Stephan, Hans-Reinhardt Brodt, Philipp de Leuw, Thomas Grünewald, Thomas Vogl, Volkhard A. J. Kempf, Oliver T. Keppler, and Kai Zacharowski

Publication: The Lancet, published: 18 December 2014

The Small Fibrinopeptide Bß15–42 as Renoprotective Agent Preserving the Endothelial and Vascular Integrity in Early Ischemia Reperfusion Injury in the Mouse Kidney

Authors: Anja Urbschat, Kai Zacharowski, Nicholas Obermüller, Katrin Rupprecht, Daniela Penzkofer, Carla Jennewein, Nguyen Tran, Bertram Scheller, Stefanie Dimmeler, and Patrick Paulus

Publication: PLOS one, published: 02 January 2014

The fibrin-derived peptide Bß15-42 attenuates liver damage in a rat model of liver ischemia/reperfusion injury.

Authors: Anding Liu, Haoshu Fang, Yan Yang, Jian Sun, Hua Fan, Shenpei Liu, Olaf Dirsch, and Uta Dahmen
Publication: Shock, published: April 2013