A new therapy to prevent

progression to severe ARDS

Welcome to COVend!

Acute respiratory distress syndrome (ARDS) is a life-threatening pulmonary dysfunction seen in intensive care patients, triggered by viral/bacterial infections, trauma, surgery, or blood transfusions. Currently, no effective pharmaceutical therapy for ARDS exist. The overall goal of the COVend Research and Innovation Action is to provide a new effective therapy for the clinical management of ARDS in mild and moderate stages, including the prevention of progression to severe disease. We aim to achieve this by testing a promising medication, the peptide FX06, in a placebo-controlled, multinational Phase II study in mild and moderate ARDS cases related to SARS-COV-2 or other aetiologies.  

Biomarker and AI-supported FX06 therapy to prevent the progression from mild and moderate to severe stages of COVID-19
BUDGET
1 M €
PARTNERS
1
COUNTRIES
1
HOSPITALS
1
SMEs
3

The aim of the COVend consortium is to deliver a new effective therapy against endothelial damage in ARDS for the clinical management of COVID-19 and other diseases.

Some of the technologies involved in the process are OMICs technologies for biomarker profiling, research on endothelial cell damage and AI for Data Analytics and modelling. 

COVend brings together an outstanding consortium of 13 partners from 11 countries with excellent scientific, clinical and organisational expertise to deliver IXION 2.0 study.

IXION 2.0 CLINICAL TRIAL

The clinical trial is the centrepiece of COVend’s work to make FX06 a viable therapy for the clinical management of ARDS in mild and moderate stages, including the prevention of progression to severe disease.

Meet COVend partners

COVend involves partners from all over Europe, with a variety of clinical sites based in different European countries, enabling the delivery of FX06 as a promising candidate to prevent endothelial damage in ARDS for the clinical management of COVID-19 and other diseases during mild and moderate stages. Hear from some COVend partners and discover how COVend is making a difference today!

News

RECAP: COVend at Euroanaesthesia 2025 – ARDS in Europe: data and clinical trials

We are proud to report a successful presence of COVend at Euroanaesthesia 2025, held in Lisbon from 25–27 May. Organised by our project partners at ESAIC, the event is one of Europe’s leading congresses for anaesthesia and intensive care professionals. This year’s edition brought together thousands of experts from across Europe and beyond to explore the latest in critical care innovation, COVend included.

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