Exciting research from COVend presented at the joint conference of the Société Française d’Immunologie & Deutsche Gesellschaft für Immunologie in Strasbourg! Our partners Zhiran Wang, Vadim Zhernovkov, Dmitri Lebedev and Günther Eissner from UCD presented their research within the COVend project.
Zhiran, who presented the poster, mimicked COVID-19 inflammation in endothelial cells with a cytokine cocktail in a special experimental setup that imitates blood flow in vessels. The drug FX06 reduced the harmful effects of the cytokines on the cells. Moreover, FX06 prevented immune cells from migrating through the cell layer (transendothelial migration), suggesting that it may also reduce the harmful effects of vascular leakage in patients.
Vadim and Dimitri performed sophisticated mass spectrometry analysis and could show that the incubation with FX06 changed the protein expression pattern of endothelial cells after cytokine stimulation. The affected proteins are involved in cytoskeleton remodeling, acute inflammatory response, and cell adhesion.
The conference was attended by scientists from all over France and Germany, with lectures, workshops and sessions on wide-ranging immunological topics and clinical research. This was an excellent forum for new ideas and international collaboration and an opportunity to highlight the importance of research in the COVend project.